東北大学未来科学技術共同研究センター(NICHe)
抗体創薬プロジェクト(加藤プロジェクト)
代表研究者:東北大学 加藤幸成
2017年度〜2021年度

 
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東北大学大学院医学系研究科 抗体創薬研究分野
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東北大学未来科学技術共同研究センター(NICHe)は、社会の要請に応える新しい技術と新しい産業分野の創出を社会へ提案することを目指し、産業界等との共同研究の推進を図り、先端的かつ独創的な開発研究を行うことを目的としています。
 
*加藤プロジェクトは、医学系研究科(医学部5号館7階)で実施しているため、東北大学未来科学技術共同研究センターがある青葉山ではなく、星陵町の住所となっています。
 
 
 
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論文一覧(NICHeの所属記載の論文)
 
2017
 
22. Yamada S, Itai S, Nakamura T, Chang YW, Harada H, Suzuki H, Kaneko MK, Kato Y*.
(*corresponding author)

Establishment of H2Mab-119, an Anti-Human Epidermal Growth Factor Receptor 2 Monoclonal Antibody, Against Pancreatic Cancer.
Monoclon. Antib. Immunodiagn. Immunother., DOI: 10.1089/mab.2017.0050, 2017 (PDF)
 
21. Chang YW, Yamada S, Kaneko MK, Kato Y*.
(*corresponding author)

Epitope Mapping of Monoclonal Antibody PMab-38 Against Dog Podoplanin.
Monoclon. Antib. Immunodiagn. Immunother., DOI: 10.1089/mab.2017.0048, 2017 (PDF)
 
20. Tamahara T, Ochiai K, Muto A, Kato Y, Sax N, Matsumoto M, Koseki T, Igarashi K.
mTOR-Bach2 cascade controls cell cycle and class switch recombination during B cell differentiation.
Mol Cell Biol., 37(24). pii: e00418-17, 2017
 
19. Itai S, Yamada S, Kaneko MK, Harada H, Kagawa Y, Konnai S, Kato Y*.
(*corresponding author)

Expression of cat podoplanin in feline squamous cell carcinomas.
Monoclon. Antib. Immunodiagn. Immunother., DOI: 10.1089/mab.2017.0046, 2017 (PDF)
 
18. Itai S, Yamada S, Kaneko MK, Chang YW, Harada, H, Kato Y*.
(*corresponding author)

Establishment of EMab-134, a sensitive and specific anti-epidermal growth factor receptor monoclonal antibody for detecting squamous cell carcinoma cells of the oral cavity.
Monoclon. Antib. Immunodiagn. Immunother., DOI: 10.1089/mab.2017.0042, 2017 (PDF)
 
17. Itai S, Fujii Y, Nakamura T, Chang YW, Yanaka M, Saidoh N, Handa S, Suzuki H, Harada H, Yamada S, Kaneko MK, Kato Y.
(*corresponding author)

Establishment of CMab-43, a Sensitive and Specific Anti-CD133 Monoclonal Antibody, for Immunohistochemistry.
Monoclon. Antib. Immunodiagn. Immunother., 36(5):231-235, 2017 (PDF)
 
16. Maekawa N, Konnai S, Takagi S, Kagawa Y, Okagawa T, Nishimori A, Ikebuchi R, Izumi Y, Deguchi T, Nakajima C, Kato Y, Yamamoto K, Uemura H, Suzuki Y, Murata S, Ohashi K.
A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma.
Sci Rep. ,7(1):8951. doi: 10.1038/s41598-017-09444-2, 2017
 
15. Itai S, Kaneko MK, Fujii Y, Yamada S, Nakamura T, Yanaka M, Saidoh N, Handa S, Chang Yao-Wen, Suzuki H, Harada H, Kato Y.
(*corresponding author)

Development of EMab-51, a Sensitive and Specific Anti-EGFR Monoclonal Antibody in Western Blot and Immunohistochemistry.
Monoclon. Antib. Immunodiagn. Immunother., 36(5):214-219, 2017 (PDF)
 
14. Itai S, Yamada S, Kaneko MK, Harada H, Kato Y.
(*corresponding author)

Immunohistochemical Analysis Using Anti-Podocalyxin Monoclonal Antibody PcMab-47 Demonstrates Podocalyxin Expression in Oral Squamous Cell Carcinoma Cells.
Monoclon. Antib. Immunodiagn. Immunother., 36(5):220-223, 2017 (PDF)
 
13. Yamada S, Itai S, Nakamura T, Yanaka M, Saidoh N, Chang YW, Handa S, Harada H, Kagawa Y, Ichii O, Konnai S, Kaneko MK, Kato Y.
PMab-52: Specific and Sensitive Monoclonal Antibody against Cat Podoplanin for Immunohistochemistry.
Monoclon. Antib. Immunodiagn. Immunother., 36(5):224-230, 2017 (PDF)
 
12. Itai S, Fujii Y, Kaneko MK, Yamada S, Nakamura T, Yanaka M, Saidoh N, Chang YW, Handa S, Takahashi M, Suzuki H, Harada H, Kato Y*.
(*corresponding author)

H2Mab-77 is a sensitive and specific anti-HER2 monoclonal antibody against breast cancer.
Monoclon. Antib. Immunodiagn. Immunother., 36(4): 143-148, 2017 (PDF)
 
11. Okagawa T, Konnai S, Nishimori A, Maekawa N, Ikebuchi R, Goto S, Nakajima C, Kohara J, Ogasawara S, Kato Y, Suzuki Y, Murata S, and Ohashi K.
Anti-Bovine PD-1 Rat-Bovine Chimeric Antibody for Immunotherapy of Bovine Leukemia Virus Infection in Cattle .
Frontiers in Immunology;8:650. doi: 10.3389/fimmu.2017.00650, 2017. (PDF)
 
10. Nakano T, Ogasawara S, Tanaka T, Hozumi Y, Mizuno S, Satoh E, Sakane F, Okada N, Taketomi A, Honma R, Nakamura T, Saidoh N, Yanaka M, Itai S, Handa S, Chang YW, Yamada S, Kaneko MK, Kato Y, Goto K.
DaMab-2: Anti-Human DGK Monoclonal Antibody for immunocytochemistry.
Monoclon. Antib. Immunodiagn. Immunother., 36(4): 181-184, 2017 (PDF)
 
9. Goto S, Konnai S, Okagawa T, Nishimori A, Maekawa N, Gondaira S, Higuchi H, Koiwa M, Tajima M, Kohara J, Ogasawara S, Kato Y, Suzuki Y, Murata S, Ohashi K.
Increase of cells expressing PD-1 and PD-L1 and enhancement of IFN-γ production via PD-1/PD-L1 blockade in bovine mycoplasmosis.
Immun Inflamm Dis. 2017 May 24. doi: 10.1002/iid3.173. (PDF)
 
8. Nuemket N, Yasui N, Kusakabe Y, Nomura Y, Atsumi N, Akiyama S, Nango E, Kato Y, Kaneko MK, Takagi J, Hosotani M, Yamashita A.
Structural basis for perception of diverse chemical substances by T1r taste receptors.
Nature Communications, 23;8:15530, 2017 (PDF)
 
7. Kaneko MK, Kunita A, Yamada S, Nakamura T, Yanaka M, Saidoh N, Chang YW, Handa S, Ogasawara S, Ohishi T, Abe S, Itai S, Harada H, Kawada M, Nishioka Y, Fukayama M, Kato Y.*
(*corresponding author)

Anti-Podocalyxin Antibody chPcMab-47 Exerts Antitumor Activity in Mouse Xenograft Models of Colorectal Adenocarcinomas.
Monoclon. Antib. Immunodiagn. Immunother., 36(4): 157-162, 2017(PDF)
 
6. Nishimori A, Konnai S, Okagawa T, Maekawa N, Ikebuchi R, Goto S, Sajiki Y, Suzuki Y, Kohara J, Ogasawara S, Kato Y, Murata S, Ohashi K.
In vitro and in vivo antivirus activity of an antiprogrammed death-ligand 1 (PD-L1) ratbovine chimeric antibody against bovine leukemia virus infection.
PLoS ONE, 12(4): e0174916., 2017 (PDF)
 
5. Yamada S, Honma R, Kaneko MK, Nakamura T, Yanaka M, Saidoh N, Takagi M, Konnai S, Kato Y.*
(*corresponding author)

Characterization of Anti-bovine Podoplanin Monoclonal Antibody PMab-44
Monoclon. Antib. Immunodiagn. Immunother., 36(3): 129-134, 2017 (PDF)
 
4. Kaneko MK, Nakamura T, Kunita A, Fukayama M, Abe S, Nishioka Y, Yamada S, Yanaka M, Saidoh N, Yoshida K, Fujii Y, Ogasawara S, Kato Y.*
(*corresponding author)

ChLpMab-23: Cancer-specific Human?Mouse Chimeric Anti-podoplanin Antibody Exhibits Antitumor Activity via Antibody-Dependent Cellular Cytotoxicity
Monoclon. Antib. Immunodiagn. Immunother., 36(3): 104-112, 2017 (PDF)
 
3. Ogasawara S, Kaneko MK, Yamada S, Honma R, Nakamura T, Saidoh N, Yanaka M, Yoshida K, Fujii Y, Kato Y.*
(*corresponding author)

PcMab-47: Novel Anti-human Podocalyxin Monoclonal Antibody for Immunohistochemistry
Monoclon. Antib. Immunodiagn. Immunother., 36(2): 50-56, 2017(PDF)
 
2. Yamada S, Ogasawara S, Kaneko MK, Kato Y.*
(*corresponding author)

LpMab-23: A Cancer-Specific Monoclonal Antibody against Human Podoplanin
Monoclon. Antib. Immunodiagn. Immunother., 36(2): 72-76, 2017 (PDF)
 
1. Yamada S, Kaneko MK, Nakamura T, Ichii O, Konnai S, Kato Y.*
(*corresponding author)

Development of mPMab-1, a Mouse-Rat Chimeric Antibody against Mouse Podoplanin
Monoclon. Antib. Immunodiagn. Immunother.,36(2): 77-79, 2017 (PDF)
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