The Adachi Laboratory
Yokohama City University
Send E-mail to: firstname.lastname@example.org
Phone: 81-45-787-2228; Fax: 81-45-787-2228
Education: Ph.D. 1994 University of Tokyo
Started at YCU: 1994
Research Topics: DNA Repair, DNA Recombination, Cell Cycle, Cancer Genetics, Cancer Chemotherapy, Human Genome and Repair Genes, Aging
Publication List (2000-2010)
The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase-IIalpha in breast cancer cells.
Cancer Res., 69:948-957 (2009)
Impact of non-homologous end-joining deficiency on random and targeted DNA integration: Implications for gene targeting.
Nucleic Acids Res., 36, 6333-6342 (2008)
NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform.
J. Biol. Chem., 283, 23711-23720 (2008)
Highly proficient gene targeting by homologous recombination in the human pre-B cell line Nalm-6.
Methods Mol. Biol., 435, 17-29 (2008)
Simple one-week method to construct gene-targeting vectors: application to production of human knockout cell lines.
Biotechniques, 41, 311-316 (2006)
Enhanced gene targeting efficiency by siRNA that silences the expression of the Bloom syndrome gene in human cells.
Genes Cells, 11, 363-371 (2006)
Heterozygous inactivation of human Ku70/Ku86 heterodimer does not affect cell growth, double-strand break repair, or genome integrity.
DNA Repair, 5, 303-311 (2005)
Genetic interactions between BLM and DNA ligase IV in human cells.
J. Biol. Chem., 279, 55433-55442 (2004)
Loss of nonhomologous end joining confers camptothecin resistance in DT40 cells. Implications for the repair of topoisomerase I-mediated DNA damage.
J. Biol. Chem., 279, 37343-37348 (2004)
Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193: implications for the repair of topoisomerase II-mediated DNA damage.
J. Biol. Chem., 278, 35897-35902 (2003)
Bidirectional gene organization: a common architectural feature of the human genome.
Cell, 109, 807-809 (2002)
DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: Implications for DNA double-strand break repair.
Proc. Natl. Acad. Sci. U.S.A., 98, 12109-12113 (2001)
Last updated: April 1, 2010