Safety Data Sheet (SDS)


2,3,7,8-Tetrachlorodibenzo-[1,4]-dioxin
CAS No 1746-01-6
Creation date: 30th Sep. 2008
1 Identification of the substance or mixture and of the supplier
1.1 GHS product identifier : 2,3,7,8-Tetrachlorodibenzo-[1,4]-dioxin
1.2 Other means of identification : Dibenzo [b, e, 2, 3, 7, 8-TCDD, 2, 3, 7, 8-TETRACHLORODIBENZO-p-DIOXIN, 2, 3, 7, 8-Tetrachloro-1, 4-dioxin
1.3 Example of use of the chemical : unwilled toxic product by burning, etc
1.4 Supplier's details (including name, address, phone number, etc) :
Company name: OOOO CO. LTD
address: OO, OO Town, KL, Malaysia
Tel: 03-0000-1234
FAX: 03-0000-1234
e-mail: OOO@OOO.co.my
emergency call: 019-OOO-OOOO

2.Hazard Identification
GHS Classification (Based on NITE)
Physical HazardsExplosivesNot applicable
Flammable gasesNot applicable
Flammable aerosolsNot applicable
Oxidizing gasesNot applicable
Gases under pressureNot applicable
Flammable liquidsNot applicable
Flammable solidsClassification not possible
Self-reactive substances and mixturesNot applicable
Pyrophoric liquidsNot applicable
Pyrophoric solidsClassification not possible
Self-heating substances and mixturesClassification not possible
Substances and mixtures which, in contact with water, emit flammable gasesNot applicable
Oxidizing liquidsNot applicable
Oxidizing solidsNot applicable
Organic peroxidesNot applicable
Corrosive to metalsClassification not possible
Human Health HazardsAcute toxicity (Oral)Category 1
Acute toxicity (Dermal)Category 1
Acute toxicity (Inhalation: Gases)Not applicable
Acute toxicity (Inhalation: Vapours)Classification not possible
Acute toxicity (Inhalation: Dusts)Classification not possible
Acute toxicity (Inhalation: Mists)Not applicable
Skin corrosion/irritationCategory 2
Serious eye damage/eye irritationCategory 2A-2B
Respiratory sensitizationClassification not possible
Skin sensitizationClassification not possible
Germ cell mutagenicityCategory 2
CarcinogenicityCategory 1A
Reproductive toxicityCategory 1B
Specific target organ toxicity - Single exposureCategory 1(skin, liver, immunity system, endocrine system, bone marrow, reproductive organ, urinary organs)
Specific target organ toxicity - Repeated exposureCategory 1(skin, liver, immunity system, endocrine system, nervous system, blood, kidney)
Aspiration hazardClassification not possible
Environmental HazardsAcute toxicity to the aquatic environmentClassification not possible
Chronic toxicity to the aquatic environmentClassification not possible

Label Elements
Pictogram and Symbol :
Signal word :Danger
Hazard statement :Fatal if swallowed
Fatal in contact with skin
Causes skin irritation
Causes eye irritation
Suspected of causing genetic defects
May cause cancer
May damage fertility or the unborn child
Causes damage to skin, liver, immunity system, endocrine system, bone marrow, reproductive organ, urinary organs
Causes damage to skin, liver, immunity system, endocrine system, nervous system, blood, kidney through prolonged or repeated exposure
Precaution :
[Prevention]
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Do not breathe dust/fume.
Do not get in eyes, on skin, or on clothing.
Wash hands thoroughly after handling.
Do not eat, drink or smoke when using this product.
Wear protective gloves/protective clothing/eye protection/face protection.
Use ventilation system or personal protective equipment as required.
[Response]
IF SWALLOWED: Rinse mouth. Immediately call a POISON CENTER or doctor/physician.
IF ON SKIN: Gently wash with plenty of soap and water. Immediately call a POISON CENTER or doctor/physician.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
If skin irritation occurs: Get medical advice/attention.
If eye irritation persists: Get medical advice/attention.
Remove/Take off immediately all contaminated clothing.
Take off contaminated clothing and wash before reuse.
[Storage]
Store locked up.
[Disposal]
Dispose of contents/container in accordance with local/regional/ national/international regulations.

3 Composition/information on ingredients
3.1 Substance : 2,3,7,8-Tetrachlorodibenzo-[1,4]-dioxin
3.2 Other name : Dibenzo [b, e, 2, 3, 7, 8-TCDD, 2, 3, 7, 8-TETRACHLORODIBENZO-p-DIOXIN, 2, 3, 7, 8-Tetrachloro-1, 4-dioxin
3.2 Chemical formula : C12H4Cl4O2
3.3 CAS number : 1746-01-6
3.5 ICSC number : 1467
3.6 EC Number
3.7 NITE number : 838
3.8 Concentration : >99%

4 First aid measures
4.1 Description of necessary measures, subdivided according to the different routes of exposure, ie, inhalation, skin and eye contact, and ingestion
IF SWALLOWED: Rinse mouth. Immediately call a POISON CENTER or doctor/physician.
IF ON SKIN: Gently wash with plenty of soap and water. Immediately call a POISON CENTER or doctor/physician.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
4.2 Most important symptoms/effects, acute and delayed
Fatal if swallowed (Acute toxicity (Oral) Category 1 )
Fatal in contact with skin (Acute toxicity (Dermal) Category 1 )
Causes skin irritation (Skin corrosion/irritation Category 2 )
Causes eye irritation (Serious eye damage/eye irritation Category 2A-2B )
Suspected of causing genetic defects (Germ cell mutagenicity Category 2 )
May cause cancer (Carcinogenicity Category 1A )
May damage fertility or the unborn child (Reproductive toxicity Category 1B )
Causes damage to skin, liver, immunity system, endocrine system, bone marrow, reproductive organ, urinary organs (Specific target organ toxicity - Single exposure Category 1(skin, liver, immunity system, endocrine system, bone marrow, reproductive organ, urinary organs) )
Causes damage to skin, liver, immunity system, endocrine system, nervous system, blood, kidney through prolonged or repeated exposure (Specific target organ toxicity - Repeated exposure Category 1(skin, liver, immunity system, endocrine system, nervous system, blood, kidney) )
Please refer to "11 Toxicological information" in detail.
4.3 Indication of immediate medical attention and special treatment needed, if necessary
If skin irritation occurs: Get medical advice/attention.
If eye irritation persists: Get medical advice/attention.

5 Firefighting measures
Acute hazards/symptoms in Fire : Gives off irritating or toxic fumes (or gases) in a fire.
First AID/Fire Fighting in Fire : In case of fire in the surroundings: powder, water spray, foam, carbon dioxide.

6 Accidental release measures
Evacuate danger area! Consult an expert! Chemical protection suit including self-contained breathing apparatus.

7 Handling and storage
7.1 Precautions for safe handling
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Do not breathe dust/fume.
Do not get in eyes, on skin, or on clothing.
Wash hands thoroughly after handling.
Do not eat, drink or smoke when using this product.
Wear protective gloves/protective clothing/eye protection/face protection.
Use ventilation system or personal protective equipment as required.
Remove/Take off immediately all contaminated clothing.
Take off contaminated clothing and wash before reuse.
7.2 Conditions for safe storage, including any incompatibilities
Store locked up.

8 Exposure controls/personal protection
8.1 Control parameters, eg, occupational exposure limit values or biological limit values
ACGIH 2006, No data
8.2 Appropriate engineering controls (Please refer to engineering controls described in "7.1 Precautions for safe handling".)
8.3 Individual protection measures, such as personal protective equipment (Please refer to Individual protection measures described in "7.1 Precautions for safe handling".)

9 Physical and chemical properties
9.1 Appearance (physical state, color, etc) : colorless-white needle crystal
9.2 Odor : No data
9.3 Odor threshold : No data
9.4 pH : No data
9.5 Melting point/Freezing point : 305-306 degree C (melting point)
9.6 Initial boiling point and boiling range : No data
9.7 Flash point : No data
9.8 Evaporation rate : not applicable
9.9 Flammability (solid, gas) : No data
9.10 Upper/lower flammability or explosive limits : No data
9.11 Vapor pressure : 1.50~10-9 mmHg (25 degree C) [converted value 1.40~10-7 Pa (25 degree C) ]
9.12 Vapor density : No data
9.13 Relative density : 1.8g/cm3
9.14 Solubility(ies) : not soluble in water,
9.15 Partition coefficient: n-octanol/water : log Pow= 6.8-7.02
9.16 Autoignition temperature : No data
9.17 Decomposition temperature : No data
9.18 GHS Classification - Physical Hazards

10 Stability and reactivity
10.1 Chemical stability : stable in common condition
10.2 Possibility of hazardous reactions :
10.3 Conditions to avoid (eg, static discharge, shock or vibration) :
10.4 Incompatible materials :
10.5 Hazardous decomposition products : CO, CO2, hydrogen chloride

11 Toxicological information
11.1 Acute toxicity (Oral)
It was set as Category 1 based on rat LD50 values: 0.022mg/kg (PATTY 4th, 1994, IARC 69, 1997, NTP TR209, 1982, ATSDR, 1998), 0.013mg/kg (IARC 69, 1997), 0.043mg/kg (IARC 69, 1997, ATSDR, 1998), 0.34mg/kg (IARC 69, 1997), 0.100mg/kg (NTP TR209, 1982), 0.190mg/kg (NTP TR209, 1982), 0.125mg/kg (NTP TR209, 1982, ATSDR, 1998), 0.060mg/kg (ATSDR, 1998), and 0.164mg/kg (ATSDR, 1998).
Fatal if swallowed (Acute toxicity (Oral) Category 1 )
11.2 Acute toxicity (Dermal)
It was set as Category 1 based on rabbit LD50 value: 0.275mg/kg (PATTY 4th, 1994, IARC 69, 1997, ATSDR, 1998).
Fatal in contact with skin (Acute toxicity (Dermal) Category 1 )
11.3 Acute toxicity (Inhalation: Gases)
Solid (GHS definition)
11.4 Acute toxicity (Inhalation: Vapours)
No data available
11.5 Acute toxicity (Inhalation: Dusts / Mist)
No data available
11.6 Skin corrosion / irritation
From description that hyperkeratosis and epidermal hyperplasia were accepted in the acute dermatitis exposure tests using the mouse (ATSDR (1998)), and description that the skin was stimulated (ICSC (J) (2003)), it was set as Category 2.
Causes skin irritation (Skin corrosion/irritation Category 2 )
11.7 Serious eye damage / eye irritation
There is the description that in the test applied to the ocular of the rabbit (ATSDR (1998)), inflammation such as conjunctival edemas was acknowledged. So it was set as Category 2A-2B.
Causes eye irritation (Serious eye damage/eye irritation Category 2A-2B )
11.8 Respiratory sensitization / Skin sensitization
No data available
11.9 Germ cell mutagenicity
Since there was a positive result in the chromosome aberration test on rat and mouse marrow cells which is an in vivo mutagenicity test with somatic cells (ATSDR, 1998), and there was no positive result in the in vivo heredity toxicity examination on germ cells. So it was classified as Category 2 .
Suspected of causing genetic defects (Germ cell mutagenicity Category 2 )
11.10 Carcinogenicity
It was classified into group 1 (IARC 69, 1997), and classified into 1 in Japan Assoc. of Industrial Health (industrial hygene academic society recommentation, 2005) and classified into K in NTP (NTP RoC 11th, 2005). So it was considered as Category 1A.
May cause cancer (Carcinogenicity Category 1A )
11.11 Reproductive toxicity
It was classified into Category 1B based on the description that reduced fertility potential was admitted in the rat fecundity study (IARC 69 (1997), ATSDR (1998), NTP TR209 (1982)), description that embryonic lethality effects, fetal malformation, and reduction of newborn baby's immunity and fertility potential, etc. were observed also in single exposure, and in the pregnant rat, mouse or hamster oral administration examination (IARC 69 (1997), ATSDR (1998), NTP TR209 (1982),) and description that fetotoxicity was observed at dose lower than causing maternal toxicity in the monkey oral administration examination (IARC 69 (1997) and ATSDR (1998)).
May damage fertility or the unborn child (Reproductive toxicity Category 1B )
11.12 Specific target organ toxicity - Single exposure
As effect by human disaster exposure of IARC 69 (1997), description that chlorance, liver-enzymes change, change of an immune systems or glucose metabolism is admitted, the description that chlorance and the effect of liver is admitted by acute exposure in humans of ATSDR (1998), and in the oral study using the guinea pigs, rats, mice and a monky of IARC 69 (1997), ATSDR (1998),NTP TR (1982), description that the effect on the immune systems thymic atrophy, etc, effect on liver such as enlargement of liver cells or vacuolation, etc., epithelium fault formation of a renal pelvis, a ureter, and a bladder, marrow, and the cell reduction in deferent, from description that the effect of the endocrine systems on changes of thyroid hormones etc. was admitted with the given dose of the guidance value range of Category 1. So it was set as Category 1 ( skin, liver, an immune systems, an endocrine systems, marrow, genitals, urinary organs)
Causes damage to skin, liver, immunity system, endocrine system, bone marrow, reproductive organ, urinary organs (Specific target organ toxicity - Single exposure Category 1(skin, liver, immunity system, endocrine system, bone marrow, reproductive organ, urinary organs) )
11.13 Specific target organ toxicity - Repeated exposure
Based on descriptions that as effect of the human occupational exposure, chloracne, in liver-enzymes change, description that change of an immune systems or sugar metabolism is observed (IARC 69 (1997)), and humans evidence of exposure, hepatotoxicity, the effect of the endocrine systems on the skin influences of chloracne etc., sugar metabolism, thyroid dysfunction, etc., and the symptoms in peripheral and a central nervous systems are observed (ATSDR (1998)), and also that in the oral study using rat,mice or guinea pigs, the effect of the immunity systems on thymic atrophy etc., the denaturation of the effect of the blood on a liver damages, a thrombocytopenias, etc., the kidney, and the thyroid gland was obsserved with the given dose of the guidance value range of Category 1 ( IARC 69 (1997), ATSDR (1998),NTP TR209 (1982)), and it was classified into Category 1 (the skin, liver, an immune systems, an endocrine systems, a nervous systems, blood, kidney)
Causes damage to skin, liver, immunity system, endocrine system, nervous system, blood, kidney through prolonged or repeated exposure (Specific target organ toxicity - Repeated exposure Category 1(skin, liver, immunity system, endocrine system, nervous system, blood, kidney) )
11.14 Aspiration hazard
No data available

12 Ecological information
12.1 Acute toxicity to the aquatic environment
Insufficient data available.
12.2 Chronic toxicity to the aquatic environment
Insufficient data available.
12.3 Other adverse effects

13 Disposal considerations
13.1 Description of waste residues and information on their safe handling and methods of disposal
If you would like to dispose of this chemical, you should properly dispose of this by yourself or ask qualified specific agents dispose of this according to related legislations and local regulations. If you would like to ask the agents dispose of this chemical, you should provide sufficient information on dangerousness and hazard of this chemical.
13.2 the disposal of any contaminated packaging
Container should be recycled after cleaning or if you would like to dispose of container of this chemical, you should properly dispose of this by yourself or ask qualified specific agents dispose of this according to related legislations and local regulations. If you would like to ask the agents dispose of this container, you should provide sufficient information on dangerousness and hazard of this chemical in this container and information on ingredient and notice of container.

14 Transport information
14.1 UN Number : 2811
14.2 UN Proper shipping name : TOXIC SOLID, ORGANIC, N.O.S.
14.3 Transport Hazard class(es) : Division 6.1: Toxic substances
14.4 Packing group, if applicable : I
14.5 Marine pollutant (Yes/No)
14.6 Special precautions which a user needs to be aware of or needs to comply with in connection with transport or conveyance either within or outside their premises

15 Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question (under survey)

16 Other information including information on preparation and revision of the SDS

(Reference)
NITE GHS Classification of this substance (English/Japanese)
GHS Model Label of this substance (English/Japanese)
GHS Model Label List of 714 Chemicals in OSH in Japan (English/Japanese)
GHS Classification Manual, Technical Guidance and Results of the classification in Japan (English/Japanese)
Technical Guidance on GHS classification in Japan (English/Japanese)
Japan Advanced Information center of Safety and Health - Chemical information (Only Japanese)
ICSC 1467 (English/Japanese )
This information was provided by the Project for Improving Occupational Safety and Health Administration of the DOSH between JICA and DOSH, Malaysia.